That difference in edema in the PSMA(+) tumor surroundings compared to the PSMA(-) tumor surroundings was attributed to the 3.2 ± 0.7 fold higher accumulation of the PSMA-targeted photosensitizer (YC-9) in PSMA(+) tumors compared to PSMA(-) tumors, before NIR irradiation for PDT. Here, FOLH1 is linked to neoplasm.