FOLH1 and neoplasm: Furthermore, although this PDT pretreatment strategy was effective in enhancing the delivery of PSMA-targeted MNPs to PSMA(+) tumors with low tumor vascular permeability, there is still a need for the development and optimization of MNP delivery strategies to increase the delivery efficiency, by minimizing the accumulation of MNPs in organs of the RES, such as the liver.