LPS: lipopolysaccharide; ARDS: acute respiratory distress syndrome; NLRP3: NLR family pyrin containing domain three; GSK‐3β: glycogen synthase kinase-three beta; SSc-ILD: systemic sclerosis-associated interstitial lung disease; TGF-β1: transforming growth factor-beta one; ERK: extracellular signal-regulated kinase; AKT: serine/threonine-specific protein kinase. The gene discussed is DYRK1A; the disease is systemic sclerosis.