After adjustment, it was independently associated with increasing age (HR 1.07 per decade above 40 years; 95% CI 1.04–1.09, p < 0.001), male sex (HR 2.31; 95% CI 1.52–3.50, p < 0.001), raised admission CRP level (HR 1.03 per 10 mg·l−1 increments above the upper normal limit of 5 mg·l−1; 95% CI 1.01–1.04, p=0.001), history of CKD (HR 1.87; 95% CI 1.21–2.89, p=0.005), and dyspnoea as a presenting symptom (HR 1.88; 95% CI 1.24–1.86, p=0.005). This evidence concerns the gene CRP and chronic kidney disease.