Among these, IDH1 (HR = 1.022, 95%CI = 1.008–1.037), G6PD (HR = 1.043, 95%CI = 1.028–1.057), HK3 (HR = 1.151, 95%CI = 1.089–1.217), ENO2 (HR = 1.088, 95%CI = 1.004–1.012), ENO3 (HR = 1.030, 95%CI = 1.007–1.054), RPIA (HR = 1.103, 95%CI = 1.041–1.170), PSAT1 (HR = 1.016, 95%CI = 1.010–1.023), GAPDH (HR = 1.000, 95%CI = 1.000–1.001), TALDO1 (HR = 1.010, 95%CI = 1.004–1.016), and PGLS (HR = 1.031, 95%CI = 1.017–1.046)—upon being expressed at high levels—resulted in a short survival duration in ccRCC patients. The gene discussed is HK3; the disease is nonpapillary renal cell carcinoma.