We performed a transcription factor network for the main differentially expressed genes of ccRCC, and several core transcriptional factors were identified: FLI1, ETS1, SREBF2, PML, CEBPB, RUNX1, MYBL2, CENPA, FOXM1, and LMNB1. Here, RUNX1 is linked to nonpapillary renal cell carcinoma.