RUNX1 and nonpapillary renal cell carcinoma: To investigate transcriptional factors upstream of the main differentially expressed genes in ccRCC, we generated a transcriptional factor network and observed that several core transcriptional factors were associated with the differentially expressed genes namely, FLI1, ETS1, SREBF2, PML, CEBPB, RUNX1, MYBL2, CENPA, FOXM1, and LMNB1 (Figure 4(d)).