CRK and leukemia: One emodin derivative, Emodin 35 (E35, C34H50 BrNO5·H2O; molecular weight, 631.29; Figure 1(a)), has been shown to downregulate TP53 protein expression and decrease PI3K/Akt protein phosphorylation in diffused large B cell lymphoma cells [8] while downstreaming Crk, Akt/mTOR, and MEK/ERK pathways in 32Dp210-T315I leukemia cells [9], inhibiting the cellular growth, and inducing apoptosis in leukemia cells [10].