Notably, IHC staining for CD31 revealed that the microvessel density was increased in tumors with high miR-1290 expression compared to tumors with lower miR-1290 expression (Figure 3(g)), which is consistent with our results showing that miR-1290 acts as an oncogene to promote tumor angiogenesis in vitro and in vivo. Here, PECAM1 is linked to neoplasm.