CCR4 and neoplasm: Moreover, an immunosuppressive tumor microenvironment, with tons of interleukin 6 (IL-6), IL-10, EBV-encoded microRNAs, and C-C motif chemokine receptor 4 (CCR-4)+ regulatory T-cells (Treg), may aid lymphoma cell survival in immunocompetent individuals [10, 31].