Meanwhile, the datasets which highly expressed C1QC or TYROBP mainly correlated with chemokine and JAK-STAT or TLR4 cascade pathway activation, respectively, which participated in diverse immune cells' functional process: the chemokine can induce macrophage polarization under inflammation stage, while JAK-STAT pathway are crucial in NK-Cells' proinflammation, and TLR4 was proved to mediate CD8+ T cells' activation in some innate immune disease [31–33]. Here, TLR4 is linked to immune system disorder.