LRP6 and colorectal carcinoma: LDL receptor-related protein-6 (LRP6), an important coreceptor in the Wnt pathway, is significantly upregulated at the transcriptional, protein and phosphorylation levels in CRC cells and tissues and is correlated with TNM or Dukes staging and a worse prognosis (Rismani et al., 2017[27]; Yao et al., 2017[40]).