Interestingly, only the hematopoietic cell lineage signaling pathway was enriched by the common DEGs, and the statistical test is close to significance (p=0.085), implying that the hematopoietic cell lineage signaling pathway “may be” an interactive linkage between CAD and AF that involves membrane metallo-endopeptidase (MME, also known as Neprilysin or Neutral endopeptidase 24.11) (Sankhe et al., 2020[41]), and TfR1. Here, MME is linked to atrial fibrillation.