Fluorescence-activated cell sorting (FACS) analysis of CD45+MHC-II+ cells from MMTV-PyMT tumors has been described to distinguish Notch-dependent, pro-tumor TAMs from homeostatic mammary tissue macrophages on the basis of the differential expression of CD11b (TAMs, CD11blow; mammary tissue macrophages, CD11bhigh) [29]. The gene discussed is ITGAM; the disease is neoplasm.