Of note, our data indicate that in the presence of tumor-derived factors, more CD206high and less CD206low BMDM are generated ex vivo from bone marrow progenitor cells but HDAC inhibition in myeloid cells attenuates this process, leading to the generation of more M1-like and less M2-like macrophages compared with that of control. The gene discussed is HDAC9; the disease is neoplasm.