We observed the species R. intestinalis associated with rs79499638 (P = 3.81 × 10−8) and rs760646544 (a insertion of CTGTT, P = 1.75 × 10−8) near PLXDC2 (related to nidogen-1 measurement and diabetic retinopathy in GWAS catalog). The gene discussed is NID1; the disease is diabetic retinopathy.