PARVB and colorectal cancer: Similarly, Parvimonas micra is enriched in colorectal cancer1, its associated host gene PARVB (Parvin Beta, rs35928604, P = 1.55 × 10−8, Fig. 4c) was overexpressed in colorectal cancer including COAD and rectum adenocarcinoma (READ) (Fig. 4e), which supported the previous study that reported overexpression of PARVB correlated significantly with lymph node metastasis and tumor invasion39.