NEGR1 and depressive symptom measurement: Rs4650205 in NEGR1-LINC01360 gene significantly associated with the abundance of genus Acidaminococcus in males (P = 4.87 × 10−8) but not in females (P = 0.48), and its proxy SNPs (linkage disequilibrium r2 > 0.6) were reported linked to multiple nervous system disorders such as autism spectrum disorder, schizophrenia, depression and migraine by substantial GWAS studies.