Next, the instrumental contribution of endogenous CD8+ T cells to antitumor activity was further corroborated by the finding that mFRβ CAR-T cells were not able to control parental ID8 tumor progression in mice that lack functional CD8+ T cells (Fig. 5n), in spite of the efficient depletion of FRβ+ TAMs (Supplementary Fig. 6h). This evidence concerns the gene FOLR2 and neoplasm.