CHD7 and Abnormal retinal morphology: In zebrafish chd7 morphants, eyes are smaller and retinal organization is disrupted with a reduction in RGC numbers and a lack of photoreceptor layer maturation [91]. Conditional Chd7 knockout in mice also resulted in dysmorphic eyes with unrecognizable optic cups and small lenses [92]. There are numerous other chromatin remodeling proteins and it will be of interest to determine whether they play roles during retinal development and/or in specific retinal cell types, as well as during the progression of retinal diseases.