It was revealed that 5 out of 19 pathogenic mutations in BRCA1 (Fig. 3A; Table 1) and 23 out of 60 pathogenic mutations in BRCA2 (Fig. 3B; Table 2) were novel mutations found in NSCLC that have never been reported in Chinese HBOC. The gene discussed is BRCA2; the disease is non-small cell lung carcinoma.