Thus, increased level of SMPD4 in cells lacking functional ALADIN accompanied by the identification of altered lipid homeostasis (dysregulated lipid metabolism has already been linked to a variety of neurodegenerative disease, e.g. [33] as verified by the results of our BODIPY-staining support the concept of a crosstalk between lipid homeostasis and nuclear envelope integrity. Here, SMPD4 is linked to neurodegenerative disease.