NPPB and hydrops fetalis: Keeping in mind the unique differences of Galectin-3 versus BNP, and the predictive power of Galectin-3 in patients who have been previously diagnosed with HF, Galectin-3 is postulated to have great potential in being able to predict left ventricular dysfunction and cardiovascular events in asymptomatic patients who are at higher risk of evolution to HF, with the notion that active fibrosis may precede clinical manifestations of HF by many years.