TNF and inborn error of immunity: The results of KEGG pathway analysis indicated that genes in turquoise modules were mainly involved in Notch signaling pathway, Chemokine signaling pathway, MAPK signaling pathway, TNF signaling pathway, and genes in blue modules were mainly implicated in Cell cycle, Primary immunodeficiency, Antigen processing and presentation, and Th17 cell differentiation (Fig. 3c, d, Additional file 4: Table S2).