Abbreviations: AnV: annexin-V; AnV/PI: annexin V/propidium Iodide; BBB: blood brain barrier; CAT: catalase; CICI: chemotherapy induced cognitive impairment; DTX: docetaxel; F2-IsoPs: F2-isoprostanes; GSH: reduced glutathione; GSSG: oxidised glutathione; MTT: cell-proliferation assay; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide compound; PI: propidium iodide; TEM: transmission electron microscopy. Here, CAT is linked to Cognitive impairment.