EGF and carcinoma: The similar medianabundance of the EGFR pathway in the normal and the carcinoma networksrequires further evaluation, but the EGF is already known to playan essential role in healthy alimentary tracts.50 The strengthening of the EGF receptor signaling pathwaybetween colon adenoma and carcinoma was previously implied in theliterature, as an increase in the EGFR copy number is detected51 and EGFR inhibitors such as cetuximab56,57 and panitumumab58 are widely used intherapy.