The EGF receptorsignaling was shown to be very important in the normal network, whichmay be because the EGF is known to be an important mediator in thealimentary tract.49 In the adenoma network,there is a significant reduction in its importance, showing that itis not the EGFR signaling that drives this pathologic transition.50 In the carcinoma network, the median abundanceis almost the same as in the normal network, indicating a significantdifference between the adenoma and carcinoma networks. Here, EGF is linked to carcinoma.