EGFR and adenoma: The decreasingEGF receptor mRNA expression in our data (8.75 in the normal network,8.06 in the adenoma network, and 5.62 in the carcinoma network) maybe caused by the possibly remarkable ratio of BRAF mutant transcriptomicdata in our data set (Materials and Methods), when the EGFR signaling pathway is constantly activated by themutant BRAF protein.51 The median abundanceof the VEGF receptor signaling is constantly growing among the threenetworks, which is significant between adenoma and carcinoma and betweennormal and carcinoma networks.