Of the SMGs found in virus-positive MCC cell lines, UM-MCC29 has a frame-shift deletion in the chromatin modifier CBX3 (chr7.26248161.A > -), and UKE-MCC3b a falsely annotated nonstop mutation in NAPA, the latter composed of an in-frame insertion (chr19.47998837.- > ATTAAA) and deletion (chr19.47998843.GTT > -), resulting in the addition of two and deletion of one amino acid without introducing a stopcodon (Figure 3F). The gene discussed is CBX3; the disease is Merkel cell skin cancer.