GHR and hepatocellular carcinoma: We performed multivariate Cox regression analysis on the identified four-gene signatures to evaluate whether each gene could reveal a significant prognosis prediction relevance for HCC patients and then we developed a risk score (RS) model using the four-gene expression profiles and their Cox regression coefficients as: RS = 0.2277∗EXP(FM83D) − 0.1554∗EXP(LCAT) − 0.0584∗EXP(ADHA) − 0.1137∗EXP(GHR), where the constant denotes the gene coefficient obtained from multivariate Cox regression and EXP denotes gene the expression level.