The comparison of the four-gene expression level between HCC and normal tissue shown in Table 2 and Figure S1 demonstrate that FAM83D was significantly over-expressed in tumors while LCAT, GHR and ADH4 were significantly downregulated in multiple GEO and TCGA datasets when compared with normal tissue (p < 0.001). This evidence concerns the gene SACK1D and hepatocellular carcinoma.