CXCL12 and plasma cell myeloma: For example, Nabissi et al. [62] have demonstrated that the CBD:THC combination reduced myeloma cell migration by down-regulating the expression of the important chemokine receptor CXCR4 that, along with its ligand SDF-1α (CXCL12), regulates in particular GSC homing to their niches [67] and critically affects GB progression.