Male NOD mice share many characteristics of ocular manifestation with SS patients including reduced tear flow [17,23,24,25,26], lymphocytic infiltration of the LG [17,24,25], development of a proteolytic and inflammatory tear film [17,27], loss of extracellular matrix [24], and altered acinar Rab3D distribution [26,28]. The gene discussed is RAB3D; the disease is synovial sarcoma.