SOD2 and cardiac hypertrophy: By targeting for 20S degradation the protein phosphatase 2A catalytic subunit α (PP2Acα), PA28γ was recently reported to cause increased phosphorylation and nuclear export of forkhead box protein O (FoxO) 3a with a subsequent decrease in superoxide dismutase 2 (SOD2), accumulation of reactive oxygen species (ROS), and emergence of cardiac hypertrophy [144].