PSME3 and cancer: Furthermore, other important processes in which PA28γ is involved, and which can help explain its cancer-promoting effects, concern its additional activities, such as immunosuppressive (see below), pro-angiogenic [118,119], and stimulation of glycolysis [104] and the epithelial-mesenchymal transition (EMT) [109,120,121], thereby aimed to adapt cell metabolism to energy starvation [122].