Moreover, treatment with a single dose of 20 μg/mL Hiltonol+++ cocktail for 72 h inhibited cell proliferation by a further 32%, suggesting the involvement of IL6/JAK2/STAT3 signaling in lung cancer progression, since AG490 and stattic (present in Hiltonol+++ cocktail) inhibited Jak2 and Stat3, respectively. This evidence concerns the gene STAT3 and lung cancer.