As a critical immune modulator, we found that a low dose of Hiltonol effectively killed lung cancer cells (Figure 1 and Figure 2), suppressed their metastasis (Figure 3), and upregulated the production of anticancer IL-24 in A549 and H292 cells, but downregulated pro-tumorigenic cytokines, GRO, MCP-1, IL-8, and IL-6 in H358 and H1299 cells (Figure 4). This evidence concerns the gene CXCL1 and lung cancer.