Figure 7A shows that the PKR and OAS mRNA levels were significantly upregulated in AD tissues, although their protein levels were reduced in NSCLC tissues (Figure 7B). Supplementary Figure S5 summarizes the clinicopathological parameters of the lung cancer patients from whom lung tissue samples were obtained. The protein expression levels of PKR and OAS were substantially and progressively reduced in advanced stage carcinoma tissues (Figure 7C). This evidence concerns the gene SMOC1 and Alzheimer disease.