Figure 5F,G shows that knockdown of PKR (or OAS) reversed the Hiltonol-mediated reduction of cell viability in NSCLC (blue boxes), resulting in the recovery of cancer cell viability and proliferation in H292 and H358 cells. Double knockdown of PKR and OAS further nullified the anticancer effect of Hiltonol as the cancer cell viability and proliferation were re-established (red boxes). Control siRNA (and without Hiltonol treatment) displayed no impact on cell viability or proliferation (Supplementary Figure S4). Here, SMOC1 is linked to non-small cell lung carcinoma.