Currently, anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) cetuximab and panitumumab, anti-vascular endothelial growth factor (VEGF) mAb bevacizumab, and anti-VEGFR2 mAb ramucirumab are approved for the treatment of patients with metastatic colorectal cancer [5,6,7,8]. Here, EGFR is linked to metastatic colorectal cancer.