Recent studies on human DAT have highlighted that mutations of this protein lead to diverse neuropsychiatric diseases [50] such as ADHD [51,52], bipolar disorder [53], PTSD [2] and to neurodegenerative disorders like dopamine transporter deficiency syndrome (DTDS) [54,55]. The gene discussed is SLC6A3; the disease is SLC6A3-related dopamine transporter deficiency syndrome.