In this context, the analysis of genomic data from The Cancer Genome Atlas Program (TCGA) database together with a proteogenomic dissection of the chromosome 8q suggested the FAK-encoding gene, namely Protein Tyrosine Kinase 2 (PTK2), as a potential candidate druggable target in breast tumors exhibiting similar gene-amplification-driven proteogenomic patterns to HER2 [10]. Here, PTK2 is linked to breast neoplasm.