In this regard, the rapid loss of FAK phosphorylation followed by poly (ADP-ribose) polymerase (PARP) cleavage was linked to a decrease of both caspase 3 activation and Akt and BCL2 associated agonist of cell death (Bad) phosphorylation toward anoikis of breast tumor cells [59]. This evidence concerns the gene PTK2 and breast neoplasm.