Likewise, the activation of fibroblast derived from mammary tumor virus-polyoma middle T-antigen (MMTV-PyMT) mouse models alongside the reduction of breast tumor cell proliferation, invasion and metastatic spread, were prevented by oroxylin A (OA) interference with the FAK and signal transducer and activator of transcription 3 (STAT3) signaling [180]. Here, PTK2 is linked to breast neoplasm.