ACTR2 and cancer: Additionally, cancer cell motility mediated by FAK activation may occur through its functional interaction with the growth factor receptor-bound protein 7 (Grb7) adaptor molecule or other components of the actin cytoskeleton remodeling like Rho family GTPases, such as Ras Homolog Family Member A (RhoA), Rac family small GTPase 1 (Rac1) and cell division cycle 42 (cdc42), neural Wiskott–Aldrich syndrome protein (N-WASP), talin, cortactin and the actin related protein 2/3 (Arp2/3) complex [87,92,93,94,95].