The main canonical mechanisms involving FAK in cancer cell adhesion and migration may include: (i) the functional interaction with c-Src, (ii) the establishment of the p130Cas/Cas/Crk molecular complex, (iii) the membrane ruffling regulated by the myosin light chain-kinase (MLCK), (iv) the recruitment of paxillin at the nascent FAs in migrating cells and (v) the activation of the Calpain-2-dependent protease activity [87,88,89,90,91]. The gene discussed is BCAR1; the disease is cancer.