In this vein, FAK inhibition both in vitro and in vivo reduced the self-renewal capabilities of the mammary ductal carcinoma in situ (DCIS) stem cells abolishing the expression of Wnt family member 3A (Wnt3a) and β-catenin, thus potentiating the effects of the irradiation therapy [159]. The gene discussed is WNT3A; the disease is ductal breast carcinoma in situ.