Likewise, in breast cancer cells overexpressing the angiotensin II type I receptor (AGTR1) the downregulation of the C-X-C Motif Chemokine Receptor 4 (CXCR4) led to lower cell contractility, pseudopodia formation and cell migration through the FAK/RhoA/ROCK1/Rho-associated coiled-coil kinase 2 (ROCK2)/pMLC transduction pathway [98]. The gene discussed is PTK2; the disease is breast cancer.