MiR-205 is downregulated in pancreatic cancer, and in an in vitro model, the overexpression of miR-205 decreased the expression of both general stemness markers such as OCT-3/4 and NANOG, and more specific pancreatic CSC markers such as CD44 and ALDH1 [80]. The gene discussed is NANOG; the disease is familial pancreatic carcinoma.