RB1 and neuroendocrine carcinoma: In the subgroup of patients with NEC, an Rb score <150 (HR 0.37, 95% CI (0.17–0.8), p = 0.012) and p16high (HR 0.39, 95% CI (0.19–0.79), p = 0.009), were both independently associated with a significantly lower risk of progression on multivariate analysis adjusted for primary tumor location, NEC subtype, Ki-67 and extra-hepatic metastases (Table 3).