B2-microglobulin (B2M) and CD58 genes are inactivated in some DLBCL cases, uncovering a mechanism of immune evasion, as B2M is involved in the expression of MHC class I, necessary for cytotoxic CD8+ T cell recognition and CD58 mediates T and NK cell response [81]. Here, CD58 is linked to diffuse large B-cell lymphoma.