The main players that support tumors, through a complex set of cytokines, receptors, immune modulators, and pro-angiogenic factors, are follicular dendritic cells (FDCs), fibroblastic reticular cells (FRCs), mesenchymal stromal cells (MSCs), and tumor-associated macrophages (TMAs), together with a rich T cell infiltrate composed of CD4 T follicular helpers (TFH) cells, CD4 T follicular regulatory (TFR) cells, CD4 T regulatory cells (TREG), and CD8 cytotoxic T cells (CTL) [9,10] (Figure 1). This evidence concerns the gene CD4 and neoplasm.