NRF2-activating mutations are rare in untreated lymphomas; however, the human DLBCL OCI-Ly19 cell line carries an endogenous point mutation in CUL3 gene (CUL3D698G) and is far less sensitive to silvestrol than other lymphoma lines and, again, this effect depends on NRF2 such that its knockdown augments silvestrol sensitivity (Figure 2F and Figure S2I). Here, CUL3 is linked to diffuse large B-cell lymphoma.