In accordance with that observed in breast and ovarian cancer, HSPB8 expression in lung adenocarcinoma (LUAC) was found to be higher in tumor tissue than in normal lung tissues, while HSPB8 overexpression enhanced cancer cell proliferation and migration; instead, the opposite effect was found after HSPB8 silencing. The gene discussed is HSPB8; the disease is lung adenocarcinoma.