HSPB8 and pachyonychia congenita: However, a recent study performed with integrated bioinformatics analysis showed that the expression levels of the transcription factor HOXB13 correlated with the aggressiveness of metastatic PC, and that HOXB13 directly regulates the expression of CIT/STK21 and HSPB8. In particular, HOXB13 negatively regulates HSPB8; in fact, HOXB13 silencing or HSPB8 induction through colchicine treatment significantly reduces the migration of highly aggressive PC cells [100].