Since HSPB8 mainly exerts action in PQC by activating CASA, a selective form of autophagy devoted to route misfolded proteins to the autophagosomes for lysosomal degradation and triggered by several stressful events, it may be possible that the adverse effects exerted by HSPB8 on tumor resistance are related to enhanced stress tolerance, allowing cells to escape from the cytotoxic properties of the chemotherapy. The gene discussed is HSPB8; the disease is neoplasm.