Moreover, the deletion c.508–509delCA (pQ170Gfs*45) and the duplication c.577–580dupGTCA (pT194Sfs*23) in the HSPB8 gene have been described as responsible for adult-onset axial and distal myopathy and proximal limb-girdle rimmed vacuolar myopathy, respectively [48,49]. Here, HSPB8 is linked to X-linked myopathy with excessive autophagy.