Moreover, a short disease duration is apparently correlated with less motor neuron loss, more microglial activity, and increased HSPB5 and HSPB8 expression, possibly because of a tight relationship in ALS between stressors (e.g., increased proteostasis and oxidative stress) and astrocyte reactivity, microglial activation, and survival [85]. This evidence concerns the gene CRYAB and amyotrophic lateral sclerosis.