HSPB8 and cancer: At the same time, HSPB8 expression is regulated by the methylation status of its promoter both in melanoma and other cancers, such as prostate cancer [115], and demethylating agents (such as 5-Aza-deoxy-cytidine) induce HSPB8 expression, together with an apoptotic response mediated by caspase-3 activation [40].