Sam68 exerts an important role in cell signal transduction, transcription, RNA metabolism, proliferation, and the survival of cancer cells [116,117,118]; thus, HSPB8 expression might be inversely correlated with the action of Sam68 and the ratio of HSPB8/Sam68 could be indicative of the proliferative potential of glioblastoma [96]. This evidence concerns the gene KHDRBS1 and cancer.