MAP3K7 and melanoma: In addition, in human melanoma A2058 and SKMEL2 cells, an inducible overexpression of HSPB8 causes DNA fragmentation due to the activation of the intrinsic apoptotic pathway mediated by caspase-9 and -3 activation [93]; HSPB8 also recruits TAK1, inducing its activation with consequent involvement of the p38-MAPK pathway.