Indeed, in atherosclerosis prone, VCAM1-deficient mice (ApoE−/−;VCAM1D4D/D4D), fatty streak formation and atherogenesis is blunted when compared to atherosclerosis-prone mice that do express VCAM1 (ApoE−/−VCAM1+/+ mice) [33]. This evidence concerns the gene VCAM1 and atherosclerosis.