EZH2 and hyperhomocysteinemia: During hyperhomocysteinemia, levels of EZH2 are increased as a result of reduced levels of miR-92a [144] and upon OSS, miR-101 expression is downregulated [110,157] also leading to an increased expression of endothelial EZH2 and the concurrent H3K27Me3 [130,144,156].