As IFN-γ plays an important role in the clearance of asexual blood-stage infection of P. falciparum, our results at transcript-level expression of exhibiting sizeable expression of this CMI effecter with transdermal immunization of PfMSP-Fu24 in the draining lymph nodes advocating for conferring protection against blood-stage infection of P. falciparum. Our results, as others [59], are in agreement to previously published findings [3,60] wherein we have shown the protection conferred by the Pf-MSP-119 against P. falciparum. The gene discussed is IFNG; the disease is infection.