Considering that LRIG1 is known as a pan-ERBB negative regulator and that LRIG1 promotes SC quiescence especially in intestinal system, it has been hypothesized that miR-92a overexpression, by LRIG1 downregulation, decreases differentiation and increases proliferative potential of ALDH-positive CSCs during CRC development [192]. This evidence concerns the gene EGFR and colorectal carcinoma.