The metastatic capacity of CRC relates to a complex between the cytoskeletal crosslinking protein Ezrin, L1CAM, and the active phosphorylated p65-subunit in the juxtamembrane region of neoplastic cells, suggesting that L1CAM-mediated activation of NF-κB signaling involving Ezrin is a key mechanism of CRC progression [156]. This evidence concerns the gene RELA and colorectal carcinoma.