Interesting results were obtained using the difluorinated curcumin (CDF), which inhibits the growth of 5-Flurouracil-Oxaliplatin-resistant HCT116, HT-29, and metastatic SW620 CRC cell lines, decreasing miR-21 levels and restoring PTEN levels with following reduction in AKT phosphorylation miR-21/AKT/PTEN axis could be responsible of differentiation of CRC cells and enhance susceptibility to therapeutic regimens [168]. This evidence concerns the gene PTEN and colorectal carcinoma.