A newly IL-6/STAT3/miR-92a/WNT axis is involved with chemoresistance, where IL-6/STAT3 pathway raise up miR-92a expression by direct target of its promoter, switching on WNT/β-catenin signaling activation by targeting KLF4, GSK3β, and DKK3, and subsequently stimulating the stem-like phenotype of CRC cells [191]. Here, STAT3 is linked to colorectal carcinoma.