EPHB2 and colorectal carcinoma: Furthermore, the activation of a conditional miR-34a allele in DLD-1 CRC cells reduces c-KIT expression and suppresses sphere formation, demonstrating that miR-34 directly targets c-KIT, interfering with c-KIT-mediated effects on CRC cells as well as expression of markers of stemness and β-catenin, activation of ERK signaling, invasion and metastasis and chemoresistance [204].