The effectiveness of 3-methoxy-6-bromosalicylaldehyde has also been tested in several pancreatic cancer cell lines: In contrast to 2-hydroxy-1-naphthaldehyde (HNA), 3-methoxy-6-bromosalicylaldehyde inhibited the splicing of XBP1 mRNA, the colony formation in vitro, and it reduced tumor size in a mouse xenograft model [117]. The gene discussed is XBP1; the disease is familial pancreatic carcinoma.