The target genes downregulated by miR-127 have been shown as follows: B-cell lymphoma 6 (BCL6) in breast cancer [41], replication initiator 1 (REPIN1) in glioma [42], formin-like 3 (FMNL3) in esophageal cancer [43], cytochrome C oxidase assembly factor 1 homologue (COA1) in giant cell tumor of bone [44], and delta like non-canonical notch ligand 1 (DLK1) in melanoma [45]. The gene discussed is COA1; the disease is melanoma.