Thus, SUMO/SIM interactions were proposed (i) to participate in liquid-like droplet formation associated with PML body assembly [52,142], (ii) to be essential for phase separation of the cytoplasmic polyadenylation element-binding protein 3 (CPEB3), which is instrumental for translation inhibition of its target mRNAs via localizing them into the cytoplasmic P bodies [143] and (iii) to be crucial for the clustering of telomeres in phase-separated nuclear condensates in certain cancer cells [144,145]. This evidence concerns the gene CPEB3 and cancer.