JMJD2B depletion reduces ERα enrichment, and estrogen stimulation leads to decreased H3K9me3 methylation levels at ERα target sites in JMJD2B-depleted T-47D human breast cancer cell line, suggesting that JMJD2B is a regulator of H3K9me3 demethylation [82]. The gene discussed is KDM4B; the disease is breast carcinoma.