Interestingly, the VAV1 expression is limited to the hematopoietic system during normal development [51] and at the same time, VAV1 remains overexpressed in hematological and lymphoid malignancies, including chronic lymphocytic leukemia (CLL) [52], acute myeloid leukemia (AML), and DLBCL [53], what is in line with our proteomic results. Here, VAV1 is linked to B-cell chronic lymphocytic leukemia.