BRAF and cancer: Importantly, the group of up-regulated proteins comprises the well-known key player proteins in cancer biology, e.g., WNT (fold change = 10.79), TRAF5 (fold change = 6.75), MAP2K1 (fold change = 5.51), (BRAF, fold change = 4.25), and caspase 9, caspase 3 and caspase 8 with fold changes of 4.69, 4.22, and 3.31, respectively.