Another study showed that linagliptin attenuated high-fat diet (HFD) and streptozotocin (STZ)-induced liver fibrosis in rats by reducing levels of inflammatory mediators, such as TNF-α, IL-6, NF-κB, and collagen depositions, accompanied by inhibiting the expression of collagen, α-SMA, and TGF-β1 in the liver [62]. Here, NFKB1 is linked to Hepatic fibrosis.