However, since hypothyroidism did not decrease the levels of p-CaMKII, p-Akt, or acetylcholine in either the Wistar or WKY rats in the present study, none of these factors seem to be responsible for the reduction in LTP in the dentate gyrus of the hippocampus observed in Wistar rats receiving PTU. This evidence concerns the gene CAMK2G and hypothyroidism.