INS and type 2 diabetes mellitus: It is essential to highlight that correlation does not imply causation; nevertheless, overexpression of RGS2 leads to reduced insulin signaling as shown in this work, and the RGS2 deficient mice are resistant to age-related weight gain [14], then it becomes imperative to explore whether a high level of RGS2 leads to a condition of poorly controlled glycemia in young T2DM subjects.