Therefore, although it has been shown the role of these RGS proteins in the regulation of metabolism, their effects are opposite: while the increase in RGS4 and RGS16 expression would substantially improve the conditions of insulin resistance and T2DM [26,27], the increase in RGS2 determine a state of insulin resistance and also, as observed in our study, its increase in T2DM patients constitutes a novel finding that could be considered as a hallmark of this condition. Here, PITX2 is linked to Insulin resistance.