On the other hand, a study in a mice insulinoma cell line (βTC3 cells) reported that RGS2 negatively modulates the insulin secretion mediated by the glucose-dependent insulinotropic polypeptide (GIP) through the GIP receptor desensitization, which could suggest a potential role in conditions associated with diabetes in humans and animal models [15]. Here, RGS2 is linked to diabetes mellitus.