Although it is well established that the development of insulin resistance is a multifactorial process, in the present report, we have studied the role of RGS2 in humans, and we show that increasing the expression of RGS2 resulted in insulin resistance in human endothelial cells and a clear correlation between uncontrolled T2DM and RGS2 expression levels in human platelets. The gene discussed is RGS2; the disease is type 2 diabetes mellitus.