However, a fundamental advancement in cell biology techniques, the induced Pluripotent Stem Cell (iPSC) derived from FOP patients, proved to be suitable for application in the study of the disease and was used to demonstrate the role of Activin A in BMP signaling starting from the mutated ACVR1 receptor [5], also reported in an article that described the first conditional ACVR1(R206H) murine model [6]. The gene discussed is ACVR1; the disease is fibrodysplasia ossificans progressiva.