GSEA analysis [21] showed that ELIdn genes were likelier to be reduced in the expression in SKCM samples, with the leading genes containing PPL, a desmosomal protein called perplakin, KCNK1, a potassium ion channel component, CAMK1D, a key serine threonine kinase in the Ca2+/calmodulin signaling, JUN, a well-known proto-oncogene, and PARD3, a cell polarity regulator and an inhibitor of glioma invasion [22]. Here, PPL is linked to central nervous system cancer.