Bisphosphonates, including pamidronate and zolendronic acid used in MM treatment, also enhance signaling through the receptor NKG2D, present not only on γδ T cells but also in CD8+T cells and NK cells, following engagement with the ligand major histocompatibility complex class-I related chain molecule A (MICA). This evidence concerns the gene KLRK1 and Miyoshi myopathy.