In addition, human RPE cells express ABCA1 and other genes involved in lipid metabolism such as SRBI, and glyburide-mediated inhibition of ABCA1 and SRBI activity was found to abolish HDL-stimulated basal efflux of photoreceptor-derived lipids in cultured human RPE cells, supporting a role of RCT regulation in the pathogenesis of AMD [286]. This evidence concerns the gene SCARB1 and age-related macular degeneration.