Moreover, while retinal abnormalities have not been reported in Tangier disease, GWAS and candidate gene studies have shown that ABCA1 gene variation contributes to AMD susceptibility, although to a lesser degree than the complement factor H (CFH) Y402H and age-related macular susceptibility-2 (ARMS2) A69S polymorphisms, which are well established risk factors for AMD [280,281,282,283,284,285]. This evidence concerns the gene ABCA1 and Tangier disease.