ABCA1 contributes to cholesterol homeostasis and participates in the pathophysiology of neurological diseases involving the accumulation of proteins in brain cells, such as traumatic brain injury, stroke sequelae, Parkinson’s disease, and Alzheimer’s disease (AD) [149,150,151,152,153,154,155,156,157]. This evidence concerns the gene ABCA1 and early-onset autosomal dominant Alzheimer disease.