CDK4 and melanoma: For the let-7a family members, under-expressed in both L-Tyr and 5-Brd-2′-dU or let-7b overexpressed in 5-Brd-2′-dU and reported as a cell cycle regulator in melanoma, possibly through cyclins D1 and D3 and Cdk4 and associated with interference with anchorage-independent growth [59].