Regarding the control of the cell cycle and senescence in B16F1 melanoma cells, where p16INK4a is truncated [41], suggests other pathways involved, such as p21, p53 pathway, cyclin D1, Cdk2, Cdk4, Rb, and transcription factors E2F [105,106,107]. The gene discussed is CDKN1A; the disease is melanoma.